文章來源:未知 文章作者:enread 發布時間:2020-02-11 01:35 字體: [ ]  進入論壇
By completing the most comprehensive study of whole cancer genomes to date, an international team of scientists has garnered1 deeper understanding of cancer, paving the way for more effective treatment, the Wellcome Sanger Institute said on Wednesday.
The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Project (PCAWG), or the Pan-Cancer Project, is a collaboration2 involving more than 1,300 scientists and clinicians from 37 countries. Researchers from the Wellcome Sanger Institute in the UK are part of the team.
They analysed more than 2,600 genomes of 38 different tumour3 types, creating a huge resource of primary cancer genomes. This was then the launch-point for 16 working groups studying multiple aspects of cancer's development, causation, progression and classification.
In a series of papers published Wednesday in the journal Nature and its affiliated4 journals, the Pan-Cancer Project discovers causes of previously5 unexplained cancers, pinpoints6 cancer-causing events and zeroes in on mechanisms7 of development.
"The genome of each patient's cancer is unique, but there are a finite set of recurring8 patterns, so with large enough studies we can identify all these patterns to optimize9 diagnosis10 and treatment," said Dr. Peter Campbell, member of the Pan-Cancer Project steering11 committee and head of Cancer, Ageing and Somatic Mutation12 at the Wellcome Sanger Institute.
Tumour types can be identified accurately13 according to the patterns of genetic14 changes seen throughout the genome, potentially aiding the diagnosis of a patient's cancer where conventional clinical tests could not identify its type, and knowledge of the exact tumour type could also help tailor treatments, according to the Wellcome Sanger Institute.


1 garnered 60d1f073f04681f98098b8374f4a7693     
v.收集并(通常)貯藏(某物),取得,獲得( garner的過去式和過去分詞 )
  • Mr. Smith gradually garnered a national reputation as a financial expert. 史密斯先生逐漸贏得全國金融專家的聲譽。 來自《簡明英漢詞典》
  • He has garnered extensive support for his proposals. 他的提議得到了廣泛的支持。 來自辭典例句
2 collaboration bW7yD     
  • The two companies are working in close collaboration each other.這兩家公司密切合作。
  • He was shot for collaboration with the enemy.他因通敵而被槍斃了。
3 tumour tumour     
  • The surgeons operated on her for a tumour.外科醫生為她施行了腫瘤切除手術。
  • The tumour constricts the nerves.腫瘤壓迫神經。
4 affiliated 78057fb733c9c93ffbdc5f0ed15ef458     
adj. 附屬的, 有關連的
  • The hospital is affiliated with the local university. 這家醫院附屬于當地大學。
  • All affiliated members can vote. 所有隸屬成員都有投票權。
5 previously bkzzzC     
  • The bicycle tyre blew out at a previously damaged point.自行車胎在以前損壞過的地方又爆開了。
  • Let me digress for a moment and explain what had happened previously.讓我岔開一會兒,解釋原先發生了什么。
6 pinpoints 42a4e5e5fdaaa77bfc7085fcb54b536a     
準確地找出或描述( pinpoint的第三人稱單數 ); 為…準確定位
  • The bombs hit the pinpoints at which they were aimed. 炸彈精確地擊中了目標。
  • There's really no point in arguing about pinpoints. 為芝麻綠豆般的小事爭論實在毫無意義。
7 mechanisms d0db71d70348ef1c49f05f59097917b8     
n.機械( mechanism的名詞復數 );機械裝置;[生物學] 機制;機械作用
  • The research will provide direct insight into molecular mechanisms. 這項研究將使人能夠直接地了解分子的機理。 來自《簡明英漢詞典》
  • He explained how the two mechanisms worked. 他解釋這兩臺機械裝置是如何工作的。 來自《簡明英漢詞典》
8 recurring 8kLzK8     
  • This kind of problem is recurring often. 這類問題經常發生。
  • For our own country, it has been a time for recurring trial. 就我們國家而言,它經過了一個反復考驗的時期。
9 optimize WIoxY     
v.使優化 [=optimise]
  • We should optimize the composition of the Standing Committees.優化人大常委會組成人員的結構。
  • We should optimize our import mix and focus on bringing in advanced technology and key equipment.優化進口結構,著重引進先進技術和關鍵設備。
10 diagnosis GvPxC     
  • His symptoms gave no obvious pointer to a possible diagnosis.他的癥狀無法作出明確的診斷。
  • The engineer made a complete diagnosis of the bridge's collapse.工程師對橋的倒塌做一次徹底的調查分析。
11 steering 3hRzbi     
  • He beat his hands on the steering wheel in frustration. 他沮喪地用手打了幾下方向盤。
  • Steering according to the wind, he also framed his words more amicably. 他真會看風使舵,口吻也馬上變得溫和了。
12 mutation t1PyM     
  • People who have this mutation need less sleep than others.有這種突變的人需要的睡眠比其他人少。
  • So far the discussion has centered entirely around mutation in the strict sense.到目前為止,嚴格來講,討論完全集中于圍繞突變問題上。
13 accurately oJHyf     
  • It is hard to hit the ball accurately.準確地擊中球很難。
  • Now scientists can forecast the weather accurately.現在科學家們能準確地預報天氣。
14 genetic PgIxp     
  • It's very difficult to treat genetic diseases.遺傳性疾病治療起來很困難。
  • Each daughter cell can receive a full complement of the genetic information.每個子細胞可以收到遺傳信息的一個完全補償物。
TAG標簽: cancer treatment genomes
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